Alexandre A da Silva Selected Research

Insulin (Novolin)

1/2023	Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease.
10/2021	Chronic Antidiabetic Actions of Leptin: Evidence From Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor.
1/2020	Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited.
1/2017	Leptin reverses hyperglycemia and hyperphagia in insulin deficient diabetic rats by pituitary-independent central nervous system actions.
6/2015	Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats.
11/2006	Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity.

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Alexandre A da Silva Research Topics

Disease

27	Obesity 05/2024 - 03/2003
27	Hypertension (High Blood Pressure) 01/2024 - 03/2003
24	Body Weight (Weight, Body) 10/2023 - 02/2004
8	Weight Gain 10/2023 - 03/2013
7	Insulin Resistance 05/2024 - 12/2004
5	Hyperphagia (Overeating) 01/2018 - 12/2004
4	Diabetes Mellitus 01/2022 - 03/2015
4	Heart Failure 01/2022 - 01/2020
3	Infarction (Infarctions) 01/2023 - 01/2021
3	Myocardial Infarction 01/2023 - 01/2021
3	Hyperinsulinism (Hyperinsulinemia) 01/2022 - 08/2005
3	Inflammation (Inflammations) 01/2021 - 03/2015
3	Weight Loss (Weight Reduction) 01/2019 - 04/2011
3	Hyperglycemia 01/2017 - 11/2006
2	Ventricular Remodeling 01/2022 - 01/2021
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 05/2011
2	Hypercapnia 01/2019 - 08/2012
2	Dyslipidemias (Dyslipidemia) 03/2015 - 12/2004
2	Abdominal Obesity 08/2005 - 02/2004
1	B-Cell Lymphoma (Lymphoma, B Cell) 05/2024
1	Non-alcoholic Fatty Liver Disease 01/2023
1	Ischemia 11/2022
1	Myocardial Ischemia (Ischemic Heart Diseases) 11/2022
1	Glucose Intolerance 01/2022
1	Albuminuria 01/2022
1	Immune System Diseases (Immune Disorders) 01/2021
1	Fibrosis (Cirrhosis) 01/2021
1	Cicatrix (Scar) 01/2021
1	Edema (Dropsy) 01/2020
1	Hypoxia (Hypoxemia) 01/2019
1	Fatty Liver 01/2018
1	Morbid Obesity 10/2017
1	Polyuria 01/2017

Drug/Important Bio-Agent (IBA)

27	LeptinIBA 11/2022 - 02/2004
15	MelanocortinsIBA 01/2021 - 12/2004
11	SodiumIBA 01/2021 - 03/2003
10	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 11/2006
8	Blood Glucose (Blood Sugar)IBA 01/2023 - 06/2015
6	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 10/2023 - 08/2005
6	Insulin (Novolin)FDA Link 01/2023 - 11/2006
6	AldosteroneIBA 01/2021 - 01/2004
6	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2019 - 06/2010
4	SHU 9119IBA 10/2023 - 06/2004
4	CytokinesIBA 01/2021 - 10/2012
4	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2021 - 03/2015
4	Angiotensin IIIBA 01/2021 - 01/2015
4	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 10/2012
4	Hypoglycemic Agents (Hypoglycemics)IBA 01/2020 - 12/2014
4	Hormones (Hormone)IBA 01/2017 - 06/2010
4	SaltsIBA 10/2012 - 12/2004
2	Proteins (Proteins, Gene)FDA Link 05/2024 - 01/2021
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2024 - 10/2012
2	Transient Receptor Potential ChannelsIBA 01/2022 - 01/2022
2	TRPC6 Cation ChannelIBA 01/2022 - 01/2022
2	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/2021 - 03/2015
2	FructoseIBA 01/2021 - 01/2018
2	Natriuretic AgentsIBA 01/2019 - 10/2012
2	ReninIBA 10/2012 - 03/2003
2	Endothelins (Endothelin)IBA 10/2012 - 02/2004
2	AngiotensinsIBA 10/2012 - 03/2003
1	PPAR alphaIBA 05/2024
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 05/2024
1	Caspase 3 (Caspase-3)IBA 05/2024
1	oil red OIBA 01/2023
1	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2023
1	Oxidoreductases (Dehydrogenase)IBA 01/2023
1	Phosphotransferases (Kinase)IBA 01/2023
1	Triglycerides (Triacylglycerol)IBA 01/2023
1	TropomyosinIBA 01/2023
1	Pyruvic Acid (Pyruvate)IBA 01/2023
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2023
1	Sodium-Glucose Transport ProteinsIBA 01/2022
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022
1	Streptozocin (Streptozotocin)FDA Link 10/2021
1	Sirtuin 3IBA 01/2021
1	TOR Serine-Threonine KinasesIBA 01/2021
1	phospholambanIBA 01/2021
1	Type 1 Angiotensin ReceptorIBA 01/2021
1	Dimethyl FumarateIBA 01/2021
1	Protein Kinases (Protein Kinase)IBA 01/2021
1	empagliflozinIBA 01/2021
1	CollagenIBA 01/2021
1	SymportersIBA 01/2021
1	BW 10IBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	Rosiglitazone (Avandia)FDA Link 01/2020
1	PPAR gammaIBA 01/2020
1	CD36 AntigensIBA 10/2019
1	NestinIBA 10/2019
1	GlucocorticoidsIBA 01/2019
1	AdipokinesIBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 11/2018
1	CatecholaminesIBA 10/2017
1	AlbuminsIBA 01/2017
1	Hexamethonium (Hexamethonium Bromide)IBA 01/2017
1	Type 3 Melanocortin ReceptorIBA 01/2016
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2015

Therapy/Procedure

5	Therapeutics 01/2021 - 03/2013
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2020
1	Ovariectomy (Oophorectomy) 11/2018